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Restless legs syndrome (RLS) is a common condition that can disrupt sleep. Keywords: restless legs syndrome, augmentation, treatment INTRODUCTION Further study with direct comparison of strategies and a larger patient population is needed to confirm our preliminary observations. The optimal approach to treating augmentation has not been established and may differ between patients. We conclude that for augmentation in RLS, gradual tapering of the augmentation-inducing dopaminergic drug is better tolerated than sudden withdrawal. Compared to sudden withdrawal, measured outcomes were similar but gradual tapering was better tolerated. Seven patients with RLS and dopaminergic drug-induced augmentation were treated with a gradual withdrawal of the offending drug and replacement with an alternative medication.

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We now report our experience with gradual withdrawal of the dopaminergic drug during the drug substitution process using a retrospective chart review with comparison to previous data. We previously reported that sudden withdrawal of dopaminergic treatment was poorly tolerated. doi: 10.2174/1874205X01509010004 Abstractĭopaminergic drugs can cause augmentation during the treatment of restless legs syndrome (RLS).

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